Masayo Takahashi, M.D.,Ph.D.
Laboratory for Retinal Regeneration.
RIKEN Center for Developmental Biology
I first met Dr.Takahashi in January, 2016 when she consulted us regarding “a method for safely transporting RPE sheets to hospitals.”
Along with Naoshi Koide, a research fellow in the Laboratory for Retinal Regeneration working on this project we held discussions to share information from the basics of what are important factors in transporting cells to how we could address the needs thereof.
These discussions led us to identify “temperature” and “vibration” as vital parameters for transporting cells.
To address temperature parameters evaluations were conducted under a temperature-monitored environment using “iP-TEC® Premier Box”, “iP-TEC® Temperature Stabilizer” and RPE sheet.
Our evaluations revealed that iP-TEC was exceptional for maintaining tenmperature stability, keeping the RPE sheet in a good condition over an extended period of time outside the incubator.
Its performance was also verified in the transport tests conducted multiple times afterward.
For addressing vibration during transport, we also held many discussions on how to transport the RPE sheets without damaging them. And from the information provided by Mr.Koide it was concluded that currently available containers could not address their needs, leading us to join hands in developing a dedicated container for this purpose.
SANPLATEC was responsible for the original plan, design and trial production and repeated evaluations and improvements were made in cooperation with Mr.Koide.
These ef forts have resulted in the development of a groundbreaking live transport container (prototype) for cell sheets that keeps them intact without damage.
“Supporting the realization of regenerative medicine.”
This fulfilling and joyous joint research project will continue.
Senior Manager, Planning
and Development Department
In order to make regenerative treatment technology a part of general medicine, a transport system ensuring stable quality, from the cell culture and processing facility to the transplantation facility, is indispensable. In particular, if the product is a homemade cell product or a custom-made product, it is irreplaceable and extremely rare, requiring a more stringent transport process management. The method of transporting regenerative medical products which are sensitive to environmental changes varies according to the product environment temperature, form, transport method and time allowance for the transport. Therefore, there is a need for a system which can flexibly address various transport conditions, and there is great anticipation toward the development of technology which can meet such a need.
Department of Cardiovascular Surgery Graduate School of Medicine Osaka
The purpose was to publicize to various countries abroad, the field of life science which the Japanese government is promoting, in particular the innovative nature of regenerative medicine. However, it was the first time to have a live myocardial sheet display. At first, we did not know the restrictions of the exhibition hall, and we could not obtain the requirement specifications needed for the mission
As an image, we wanted to have a simple system which did not require the use of electricity or control device. At that time, we heard that SANPLATEC can provide custom-made products and that you were engaged in a trial production of open-type containers with iPS Portal Inc. We thought that you would have an understanding toward our research and mission. There are other types of Temperature Stabilizer (Phase Change Material) and transport containers; however, it is important to think of what method is best in terms of the characteristics of the “object being transported.” SANPLATEC creates products with emphasis on this factor. In addition, the proposal that we received which enabled having a “display with no power source” with Temperature Stabilizer (Phase Change Material) and acrylic processing technology was a contributing factor as well.
That’s right. The exhibition spanned over 5 days, and before the start of the exhibition, you helped us simulate at what timing in the Temperature Stabilizer (Phase Change Material) require changing and adjusting, and what equipment is required in the adjustment, etc. Before the requirement specifications were determined, you gave us comprehensive advice.
Regarding the quality retention of the transported cell sheets, there is the issue of degeneration from the time of delivery to transplantation. In particular, what should be the temperature range during transport? Preparation of variations in transport temperatures will further be required. We look forward to developments in this area as well.
Atsuhiro Saito, Ph.D.
Department of Translational Cell Therapy
Osaka University Graduated School of Medicine
Medical Center for Translational Research,
Osaka University Hospital
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